Project STRONG Comparative Risks and Benefits of Gender Reassignment Therapies aimed to examine short- and long-term physical and mental health outcomes experienced by transgender and gender nonconforming individuals who underwent or are undergoing hormonal and/or surgical gender confirmation interventions. Project STRONG Cohort Study of Mortality and Morbidity in Transgender Persons aimed to understand mortality – from all causes – among transgender and gender nonconforming individuals and to assess the occurrence of chronic age-related conditions, mental health problems, and sexually transmitted diseases and among transgender patients.